If you have a family history of cancer or exhibiting signs and symptoms of cancer (abnormal changes in the breast, skin abnormalities, an abnormal lump under the skin, change in bowel habit, feeling weak, night sweat, unusual bleeding, and abnormal changes in bowel habit) your doctor might need to perform additional test to confirm the diagnosis. (4, 6) A high MPV can be linked with the following:Ī high MPV is linked with platelet activation as a result of an encounter of platelets to tumor by-products. However, if your MPV is high and your platelet count is low, it could indicate a possible bone marrow disorder (rapidly producing platelets) leading to the destruction of the older platelets. If the mean platelet volume is high, it means that your platelet is higher than the average, which means that you are producing too many platelets.